Astrovirus and the microbiome

Rotavirus and Astrovirus

Astrovirus Pathogenesis

Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge...

Astrovirus Diagnostics

Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, novel human astrovirus (HAstV) strains have been found in immunocompromised indiv...

The Astrovirus Capsid: A Review

Astroviruses are enterically transmitted viruses that cause infections in mammalian and avian species. Astroviruses are nonenveloped, icosahedral viruses comprised of a capsid protein shell and a positive-sense, single-stranded RNA genome. The capsid protein undergoes dramatic proteolytic processing both inside and outside of the host cell, resulting in a coordinated maturation process that aff...

Astrovirus Replication: An Overview

Human astroviruses are important pathogens that cause gastroenteritis worldwide. Significant progress has recently been made regarding the characterization of the RNA replication process, the apoptotic response induced in virus-infected cells, and the formation of virus-like particles. First, a relationship between astrovirus RNA replication sites and the endoplasmic reticulum-derived membranes...